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Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects

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Even with very low serum B12 concentrations (i.e., below 75pmol/L), clinically diagnosable symptoms of B12 deficiency are said to be apparent in only about 50% of people (Stabler et al., 1990)