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To successfully discriminate the regions in MRP1 that selectively control the stimulated mode of GSH transport from the basal transport of GSH, we decided to follow the strategy of chimera constructs to localize and characterize the substrates-binding sites 19,20

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Kalghatgi and Spina then did a series of biochemical tests, which showed that the same three antibiotics damaged the DNA, proteins and lipids of cultured human cells exactly what one would expect from oxidative stress

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