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Rapid mechanisms of glucocorticoid signaling in the Leydig cell

Vincristine, a chemotherapeutic agent, is known to cause neurotoxicity by decreasing levels of the antioxidant protein Nrf2 and its downstream targets HO-1 and NQO1

In several experimental models of autoimmune diseases (including thyroiditis), EVOO components, oleic acid, hydroxytyrosol, oleuropein, and oleocanthal, have proven effective in counteracting inflammatory and oxidative imbalances, suggesting their efficacy in preventing autoimmune diseases [62, 136, 137]

The majority of subjects were male (64.95%) and had inflammatory bowel disease (IBD) (78.62%)

the dosing is based on weight for patients under 50 kg