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10.3390/ijms21072358 89 RutterB

Creatine helps rapidly regenerate ATP through the phosphocreatine system

In our simulations (Figure7, panels A and B) liver GSH declines to 70% of normal and plasma GSH declines to 88% of normal

Within this integrated model, UA-driven mitophagy initiation, ALA-supported flux completion, and EGT-mediated mitochondrial stabilization converge to modulate the ferroptosismitophagy regulatory axis in cardiometabolic pathology through complementary mechanisms