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It was established that Epitalon promotes signal transducer and activator of transcription 1 (STAT1) phosphorylation, potentially through a receptor-independent mechanism that does not include interactions between IFN- and IFN-R, as seen by the lack of effect on IFN- production

The increased glomerular permeability and subsequent interactions between tubular injury, tubulointerstitial inflammation, and the progression of lupus nephritis (LN) towards renal dysfunction result in additional tissue damage in lupus

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Analysis was performed using the LC-20 Prominence HPLC system (Shimadzu, Kyoto, Japan) coupled to a LTQ Orbitrap XL Hybrid Ion Trap-Orbitrap Mass Spectrometer (Thermo Fisher Scientific) according to 1 ) with a mixture of water and acetonitrile, both containing 0.1% formic acid