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Symptoms Linked to HNMT Dysfunction Because HNMT primarily operates in tissues and the central nervous system, impaired HNMT activity is particularly associated with neurological and systemic histamine symptoms, such as brain fog, headaches and migraines, sleep disturbances, anxiety, and skin reactions like flushing and itching

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doi: 10.1016/j.ajhg.2019.12.006

A wheal can result when injected liquid medication causes the skin to rise