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NICE guidance emphasises the importance of investigating the underlying cause of B12 deficiency rather than simply treating with supplements, as this may identify serious conditions requiring specific management

For researchers exploring alternatives to gavage, encapsulation remains the most reliable method to balance stress reduction, dose certainty, and taste elimination, provided the delayed absorption window is compatible with behavioral testing schedules

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Plastic: Not all plastics are suitable for storing distilled water

Both drugs carry a black box warning for thyroid C-cell tumors, although this has primarily been observed in animal studies