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In the present study, we found that high doses of iron decreased the survival rate of mice after 8 weeks of feeding, which may be related to high-iron induced liver injury as well as other internal organ lesions [33]

In addition, upregulated expression of TXNIP (Thioredoxin Interacting Protein, TXNIP) in LSEC has a protective effect in improving ALD

To corroborate the docking outcomes, a comprehensive assessment ensued, involving 150 ns molecular dynamics simulations to unravel the dynamic interplay between the identified phytocompounds and the GR enzyme