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The sample is n=36, divided into 2 groups

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that is, if 14 patients were treated for 4 years with metformin 850 mg t.d.s., one would develop vitamin B12 deficiency

In the SURPASS-CVOT trial, tirzepatide met its primary endpoint of non-inferiority to dulaglutide for MACE-3, though it lacks an FDA-approved MACE-reduction indication in the U.S.[2] Post hoc cardiorenal analyses examined outcomes beyond the primary MACE endpoint in patients with concurrent cardiovascular and renal risk [3]