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Additionally, we particularly thank Professor Ara Koh, from Pohang University of Science and Technology for significant assistance with this study

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Blood pharmacokinetics and biodistribution of T-AsiG-CPL in vivo Encouraged by the effective PDAC cell growth inhibition and PSC quiescence in vitro, we further investigated the pharmacokinetics and bio-distribution of T-AsiG-CPL in an orthotopic pancreatic tumor mouse model, which was established by co-inoculation of mice with T3M4-luci cells and PSC that has been demonstrated to closely resemble human pancreatic cancer by generating desmoplastic stroma 29,30

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The findings suggested that the anti-aging effects of CASIN were facilitated by 60S ribosomal protein L4 (RPL4), which played a role in collagen synthesis and influenced fibroblast cytoskeletal morphology (Haydont et al., 2019)