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Ferroptosis in CD8+ T cells promotes the anti-tumor function through activating the JAK/STAT pathway, which limits cystine absorption by tumor cells (90)

Building upon these findings, a subsequent Phase III study (NCT04571164) was conducted to further evaluate the tolerability, safety, and pharmacokinetics of LY03003 in a larger cohort of PD patients, aiming to optimize dosing regimens and confirm its potential as a long-acting therapeutic option 143

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Nat Genet 46(4):357363

10.1038/s42255-018-0009-4 Nat