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Additionally, it was demonstrated, that failure PINK/PARKIN axis expression favors the accumulation of defective mitochondria that are not removed from the cells due to the impaired lysosomal system which in consequence promotes cellular damage, generates oxidative stress, and impairs sensitivity for insulin [60]

Simplified cycle: GSH participates in peroxide reduction GSSG is formed glutathione reductase and NADPH regenerate GSH

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Reduced or oxidized His-roGFP2 samples were prepared at a final concentration of 2 M by pre-incubation with 10 mM DTT or 10 mM H 2 O 2 , respectively