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Molloy, in Reference Module in Biomedical Sciences, 2014 available online at sciencedirect.com/topics/bi

IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

General guidelines suggest individuals under 150 pounds may start with 50-75mg daily, those between 150 and 200 pounds typically use 75mg daily as a standard protocol, and individuals over 200 pounds may need 75-100mg daily for optimal effects