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Recent metanalysis have revealed significant increase in oxidative stress markers such as MDA and a substantial depletion of antioxidants such as catalase, GSH in the blood, and postmortem brain of PD patients compared to healthy controls 25

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Concept, classification, and production of EVs General concept of EVs EVs, a class of cell-derived membrane structures enclosed by a bilayer lipid membrane, are nanometer- to micrometer-sized particles incapable of self-replication [12]