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Nutrients 7:89168929

(For example, PDE-3 is the phosphodiesterase inhibited by pimobendan, thereby increasing cardiac contractility.) In a July 2018 article, medical researchers report finding that, "The combination of effects [of ITI-214] in both dog and rabbit results in a rise in cardiac output with negligible changes in cardiac preload and arterial systolic pressure." ITI-214 is a product of Intra-Cellular Therapies, Inc

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This means that the rate of fatty acid oxidation could be maintained while glucose utilization decreased, and muscle glycogen could be maintained for maximal rates of oxidative ATP production and avoidance of muscular fatigue [50]