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Clinical signs of bleeding depend on duration and severity of vitamin K deficiency and include prolonged bleeding from minor wounds, spontaneous hematoma formation, intracavitary hemorrhage, and death due to blood loss and acute hemorrhagic shock

To address this issue, we treated Apc +/Min /Stard7 Lox/lox and Apc +/Min /Stard7 IEC mice with the mTORC1 inhibitor Rapamycin and assessed the consequences on mTORC1 activity as well as on tumor number and size