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The non-surgical alternative therapies discussed in this study are successful without reconstruction and are regenerative

Notably, Erastin-induced GSH depletion also promotes cardiolipin peroxidation, which not only triggers the opening of the mitochondrial permeability transition pore but also induces caspase-dependent and -independent apoptosis [218, 220,221,222]

In this context, microneedling monotherapy means microneedling without any additional topical medications

World Appl Sci J 18:704714 Hammouh F, Zein S, Amr R, Ghazzawi H, Muharib D, Al Saad D, Subih H (2020) Assessment of dietary selenium intake of Jordanian adults in Madaba: a cross sectional study