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10.1016/j.bcp.2022.115261 99 SolioM.LarrayozI

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Mitochondria, crucial organelles, play a key role in substance metabolism via oxidative phosphorylation to generate ATP

Abstract Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by the inability of phagocytes to produce reactive oxygen species (ROS) owing to a defect in any of the five components ( CYBB /gp91phox, CYBA /p22phox, NCF1 /p47phox, NCF2 /p67phox, and NCF4 /p40phox) and a concomitant regulatory component of Rac 1/2 and CYBC1/ Eros of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex

The researchers discovered that both patient cohorts exhibited significant signs of elevated oxidative stress and consequent mitochondrial damage