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The newly identified features of the disease increasingly regard PAH as a multipronged disease involving multiple points of interaction between genetics, metabolomics, imbalance of vasoconstrictor and vasodilator responses, endothelial and smooth muscle dysfunction, thrombosis and platelet dysregulation, and mitochondrial and miRNA abnormalities

In mice, repression of Fxr decreases the expression of Cyp7a1 , hepatic bile salt synthesis, and hence cholesterol solubility

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Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis

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