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Retatrutide is a triple agonist acting on GLP-1, GIP, and glucagon receptors, with phase 2 data published in the New England Journal of Medicine (2023) showing substantial weight reduction

Sources Gastroenterology: PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation Alpha-MSH Related Peptides: A New Class of Anti-Inflammatory and Immunomodulating Drugs Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis Journal of Leukocyte Biology: Antimicrobial Effects of Alpha-MSH Peptides National Institute of Diabetes and Digestive and Kidney Diseases: Ulcerative Colitis MedlinePlus: Make the Most of Your Doctor Visit Medically reviewed by

Belousoff, Rachel M

It avoids medical claims or usage guidance and instead focuses on presenting investigational context in a clean, scannable format suitable for research-focused audiences

Given as a subcutaneous injection, near the area of interest for localized effects or in the abdomen for systemic goals (gut, general recovery)