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An amide derivative 13d (Ca2+ flux IC50 = 188 nM, [brain]/[plasma] = 0.97 @ 8 h in rat), for example, showed a 10% decrease in 24-hour food intake in rats, and over 5% body weight reduction after 14-day oral treatment in diet-induced obese (DIO) mice (180)

Multiple approaches were investigated across academic and industrial laboratories, including enteric coatings to bypass stomach acid, protease inhibitor co-formulations, nanoparticle encapsulation, mucoadhesive delivery systems, and permeation enhancers

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