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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Targeting key regulators in glutamine metabolism, such as glutaminases and glutamine transporters, prompts the discovery of druggable targets and promising anti-cancer drug candidates (Fig

10.1055/s-0028-1088314 [DOI] [PubMed] [Google Scholar] Seelinger G., Merfort I., Wlfle U., Schempp C

Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D et al (1998)

In addition, itaconate was investigated for its role as an anti-inflammatory and antioxidant metabolite of the TCA cycle [124]