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386,387 Vitamin B12 supplementation has also been found to reduce symptoms in patients being treated with antidepressants: in a trial that included 73 patients taking antidepressants for major depression, 100% of participants who received intramuscular injections of 1,000 mcg B12 weekly for six weeks had 20% or greater improvement in depression scores, while only 69% of those not receiving B12 had the same degree of improvement

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Hence, this present study hypothesized that for adequate protection against oxidative stress in the liver by Chlorella vulgaris it should be capable of increasing expression of proteins that are specific for the enhancement of the free radicals scavenging