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both deliver B12 effectively into the bloodstream and bypass the gut

Doctors look at many things to decide how often you should get B12 shots

Most antibiotics, methotrexate, and primethamine may invalidate folic acid and cyanocobalamin values in blood tests

In the duodenum, pancreatic enzymes degrade the R-protein-B12 complexes, freeing B12 to bind with intrinsic factor (IF) , a glycoprotein produced by gastric parietal cells in the stomach lining