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They have been shown to reduce serum levels of C-reactive protein (CRP) (by 2038%), lipoprotein-associated phospholipase A2, interleukin (IL)-1 and IL-6 (by 1214%), and tumor necrosis factor-, among others, and boost levels of IL-10, a potent anti-inflammatory cytokine [6468]

Barkoula, Christiana Ioannou, Martina Rekatsina, Kassiani Theodoraki, Panagiotis Zis Clinical Autonomic Research.2026

More importantly in the context of the present considerations, DNA-containing immune complexes - like other DNA/protein complexes - present another means of facilitated uptake of cfDNA into immune cells, e.g., into monocytes (252), i.e., they allow for the sensing of self-DNA by TLR9 and thereby stimulate cytokine production (241, 252254)

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