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However, in rare cases, very high doses may lead to mild side effects such as headaches, nausea, diarrhea, or skin reactions like itching and rashes

Pain 153 , 18151823 (2012)

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Vitamin B12 deficiency has become common in those subject to alterations in the acidity of the digestive tract, those who follow a vegetarian or vegan diet, and those who frequently undergo antibiotic treatments