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This article reports a highly innovative approach to design safer opioid pain killers, in which ligand docking to a pathological (acidic) receptor structure identifies a MOR agonist acting at the receptor only under conditions of inflammation, leaving other receptors at rest

analogs or growth factor mimics of the present invention may also be represented as comprised of four elements joined by covalent peptide or reduced peptide bonds, as follows: I an acid such as heptanoic, hexanoic, pentanoic, butyric, proprionic, acetic, benzoic, or substituted benzoic acid, and isoforms thereof

Unlike pharmaceutical sleep aids that force sedation by suppressing brain activity, DSIP works with your body's own sleep regulation systems

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