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At least 7 types of GPXs have been identified (5,6), and their properties will be collected in a table divided into the following types: cytosolic- (cGPX or GPX1), gastrointestinal- (GI-GPX or GPX2), plasma- (pGPX or GPX3), phospholipid hydroperoxide- (PHGPX or GPX4) glutathione peroxidase, GPX5 and GPX6

Genetic and biochemical tests reveal that AFAs inhibit POD-2, encoding an acetyl CoA carboxylase, the rate-limiting enzyme in lipid biosynthesis

Substitution of the primary aromatic amine for a nitro group (SRS8-24), or elimination of the N-cyclohexyl moiety (CA-1), destroyed the antioxidant capability of Fer-1, as well as its ability to prevent erastin (10 M)-induced death in HT-1080 cells (FIGS

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As discussed in the following sections, alcohol may induce such injuries through several mechanisms, including alterations in the lung epithelial barrier, reduced ability of lung cells to remove foreign materials (mucociliary clearance), and impairment of the defensive immune response