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According to clinical research parenteral administration (intramuscular or intravenous) is preferred over other drug administration routes in case of emergency situations as it provides first-pass metabolism avoidance, reliable therapeutic concentrations and better bioavailability of dosage (2) It can also be used in situations when oral route is not feasible

The COR-I trial, involving 1,742 participants over 56 weeks, demonstrated 6.1% average weight loss with Contrave versus 1.3% with placebo (Greenway et al., Obesity, 2010)

Our large sample size enabled us to demonstrate a U-shaped relationship between folate and FPG levels and may explain the opposite associations reported in different populations

Now, the timing may be different based on how low your B12 levels were to start with

Patients should talk to their oncologist about their own risks