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ERK1/2 & VEGFR2 Mechanism Musculoskeletal Scoping Review (PMC, 2025) A 2025 scoping review confirmed BPC-157 activates VEGFR2 and drives nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilisation

To enhance thrombus-targeting capability, the LMWH-derived amphiphile was further functionalized with CREKA, a peptide ligand that can target thrombi by specifically binding to fibrin and clotted plasma proteins 37,38,39