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Diseases associated with glutathione peroxidase 4 (GPX4) are often associated with Sedaghatian-type spondylometaphyseal dysplasia, and Nrf2 superactivity is a multisystem disorder characterized by hypohomocysteinemia, failure to thrive, immunodeficiency, and neurodevelopmental abnormalities

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The process(es) that may drive this are unknown but could potentially involve posttranslational modifications such as phosphorylation or regulation of allosteric disulfides or may require interactions with proteins or lipids at the erythrocyte plasma membrane