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On the other hand, endocrine fibroblast growth factor (FGF) analogs have emerged as a promising class because of their ability to not only act directly on liver, but also to shift whole-body metabolism to a healthier state

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In osteoarthritis (OA) models, NOX1-induced oxidative stress triggers chondrocyte ferroptosis by suppressing the NRF2/HO-1 pathway, highlighting the role of specific ER isoforms and GPER1 in NOX1 activation [60]

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