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The published incidence figures are high, but they are not 100%

A typical protocol looks like this: Initial loading (for severe deficiency or pernicious anemia): Daily or every-other-day injections for 1 to 2 weeks, then weekly for 4 weeks Maintenance (pernicious anemia, ongoing absorption issues): Monthly injections indefinitely General wellness or dietary deficiency: Once every 1 to 3 months, depending on levels Your provider will check your B12 blood levels and recommend the right schedule for you

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For SC injections, the medication is placed in the soft, fatty tissue directly beneath the skin, with the needle angled at roughly 45 degrees

Klee GG: Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B[12] and folate