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Ischemic Injuries Ischemic-reperfusion (I/R) injuries such as myocardial infarction and stroke are primarily associated with systemic inflammation, a burst of circulating ROS, and organ damage from cell death

This inflammatory process includes microglial activation, increased cytokine release, and increased oxidative stress, as well as changes in glutamatergic system regulation that may exacerbate astrocyte atrophy and local damage following these events (48)

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Annu Rev Pharmacol Toxicol 2005

Hydroxytyrosl is also reported to induce Nrf2 in PI3K dependent manner (Martn et al., 2010)