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Mechanistically, BHB enhances BDNF expression in the hippocampus of mice through epigenetic modulation, including inhibition of class I histone deacetylases, and through activation of CREB (cyclic adenosine monophosphate (cAMP) response element-binding protein)-dependent transcriptional pathways [59]

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The senescence-associated secretory phenotype (SASP) emerges as a central regulator, propagating chronic inflammatory states and metabolic dysfunction (403)