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Under oxidative stress, cells with high BH4 levels can synthesize CoQ10 to alleviate oxidative damage

Early manifestations include anxiety, headache, giddiness, inability to focus the eyes, and mydriasis

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Taken together, interactions of kratom alkaloids with drug-metabolizing enzymes and cellular barriers not only affect their tissue distributions and the concentrations at target receptor sites to elicit functional responses, but also distributions, and functional responses of other drugs