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Holding the B12 in your mouth for as long as possible is best for maximizing absorption through the sublingual route

A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

Look for Clean Ingredients: Avoid supplements filled with sugars, artificial dyes, or unnecessary binders

Meaningful cosmetic changes often appear between three and six months of daily use