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For instance, Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (in PD, AD, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (PD), is a stress marker (temporal lobe epilepsy), and also protects cells from cerebral ischemic injury

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BHK-7with its high viral yieldrepresents a promising substrate for industrial-scale inactivated FMD vaccine production ( Future studies should prioritize causal validation of identified TFs: CRISPR/Cas9-mediated knockout or overexpression of candidate TFs (e.g., Runt or zf-C2H2 family members) in parental BHK-21 cells, followed by quantitative assessment of FMDV replication, will test their necessity and sufficiency for conferring proviral or antiviral phenotypes