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Glantzounis G, Tsimoyiannis E, Kappas A, Galaris D

administered AAV serotype 8-mediated gene therapy, derived by cloning hABCB4 cDNA into a modified AAV expression cassette, as a single dose to ABCB4 knockout mice and found restoration of biliary phospholipid excretion with normalization of plasma alkaline phosphatase and bilirubin

This provides an important theoretical basis for studying the interaction between mitochondrial dysfunction and diabetic ketoacidosis and may have implications for developing new treatment strategies targeting DKA

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