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Inversely, arginase 1 (ARG1) is constantly expressed by anti-inflammatory M2 macrophages

Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism

61 GilliesG

Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis

Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]