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Kolbrink B, von Samson-Himmelstjerna FA, Messtorff ML, Riebeling T, Nische R, Schmitz J, et al

49 This stage has the highest risk of mortality, which is most frequently due to multi-organ failure

If the solution looks normal, and the temperature stayed within acceptable range, and the total unrefrigerated time is under 21 days, the medication is likely still usable according to the manufacturer guidelines