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(2012) discovered Tie2-positive (Tie2+) and disialoganglioside 2-positive (GD2+) progenitor cell populations in the nucleus pulposus of mice and humans, which formed spheroid colonies expressing type II collagen and aggrecan

ZO1 activity is regulated via MLCK (myosin light chain kinase) pathway and, thus, this protein represents another interesting target of gut barrier function

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In musculoskeletal research models, it has been associated with altered fibroblast behavior and extracellular matrix organization

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