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The characteristic hypermethylation within promoter regions of colorectal cancer tumor suppressor genes indicates that the epigenome likely plays a key role in mediating non-genetic sequence modifications driving malignant phenotype (182)

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When B12 is deficient, then melanin is produced at a slow rate, hence the skin becomes spotted or patchy

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Besides, the G2/M cell cycle arrest resulting from modulation of p27, Cyclin B1, and Cyclin E impairs growth and enhances cell death

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doi: 10.1111/mmi.13073 116 SrivastavaS.BattuM

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