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The following timeframes are supported by clinical trial data and prescribing information: Nausea: Most commonly peaks in the first one to two weeks at each dose level, then improves significantly over weeks three to four

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A patient who had numerous amalgam fillings for thirty years, then had them removed a decade ago, may show relatively low blood mercury today while still carrying significant mercury accumulation in the brain and kidneys from prior decades of exposure

The preclinical case is the broadest in its class a 2025 systematic review screened 544 articles across gut lining, tendon, muscle, blood vessel lining, and nerve tissue