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Interestingly, the anti-manic effects of lithium have been proposed to occur via a mechanism that involves synaptic scaling [108]

A large molecule such as a peptide is primarily localized within the central compartment, and thus a small volume of distribution is expected

Nanomedicine 20 (4), 355369

Adrian, S., Scherzinger, A., Sanyal, A., Lake, J., Falutz, J., Dub, M., Stanley, T., Grinspoon, S., Mamputu, C., Marsolais, C., Brown, T., & Erlandson, K

Downregulation of hypoxia-inducible factor-1alpha by RNA interference alleviates the development of collagen-induced arthritis in rats