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The suppression of invasion via inhibition of cellular metabolism in GBM is subject to the same difficulties faced by pharmacologic treatments of any disease of the central nervous system, that is, penetration of the BBB (Strickland and Stoll, 2017)

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In addition, RSV enhanced BSH enzyme activity via boosting the number of BSH-producing bacteria, including Bifidobacterium and Lactobacillus , to promote BA catabolism and fecal excretion in the intestine, downregulated OST, OST expression to reduce BA reabsorption transport, and reduced CDCA content to suppress enterohepatic FXR/FGF15 axis in order to promote hepatic BA synthesis ( 3.5 TCM adjusts TMAO production to improve LMD It was found that serum lipid and TMAO levels were significantly decreased in HFD-induced AS model animals after treatment with Ginkgolide B (GB) (Lv et al., 2021), Eucommia ulmoides extract (Sun, 2020), HYQT (Sui et al., 2021a) and AOB (Zhu, 2021)

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Microglial cells induce cytotoxic effects toward colon carcinoma cells: measurement of tumor cytotoxicity with a -glutamyl transpeptidase assay