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whether contrast-induced oxidative stress acts as a direct trigger, or if other intermediates (e.g., endoplasmic reticulum stress and mitochondrial dysfunction) are involved, requires definitive validation

On the contrary, a high level of ROS may overload the capacity of the intracellular glutathione peroxidase detoxification system and hence cause apoptosis induced by lipids peroxidation, mitochondria permeabilization, and the accumulation of fatal DNA damage [14]

A PubMed search for "pentadeca arginate" returns zero results

Available online at: (Accessed September 17, 2025)

Warshaw JB, Wilson CW, Saito K, Prough RA 1985 The responses of glutathione and antioxidant enzymes to hyperoxia in developing lung