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Description

Going from tirzepatide to semaglutide means losing GIP receptor activation entirely

doi: 10.1016/j.dcn.2018.05.004 37 AndreiniCPutignanoVRosatoABanciL

PLoS One 7(3):e33232

Front Nutr 2022

It is noteworthy that Pt-induced ROS production impairs antioxidant enzymes [e.g., superoxide dismutase (SOD) and catalase (CAT)] to trigger oxidative stress (Khasabova et al., 2019), which participates in the onset and progression of both acute and chronic PIPN