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Metabolic regulation of cell growth and proliferation

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The tripeptide exists intracellularly either in an oxidised glutathione disulphide (GSSG) or reduced state (GSH), and maintaining an optimal GSH:GSSG ratio in the cell is critical for prevention of oxidative damage and for cell survival (Fig

The deregulation of respiratory chain enzymes firstly decreases ATP synthesis and secondly overproduces ROS, which cannot be neutralized by the cell