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Neurosurg Clin N Am

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After the initial response to the initial direct injury (cytoprotection), the afforded response against the repeated direct injuries (adaptive cytoprotection) does not start immediately, and thereby in meantime, special threat to the stomach temporarily left without any defense (1-3)

[18] The protonated form is highly water-soluble and relatively stable, but can become oxidized if exposed to oxygen or other oxidants